Mechanical deformation induces depolarization of neutrophils

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Mechanical deformation induces depolarization of neutrophils

The transition of neutrophils from a resting state to a primed state is an essential requirement for their function as competent immune cells. This transition can be caused not only by chemical signals but also by mechanical perturbation. After cessation of either, these cells gradually revert to a quiescent state over 40 to 120 min. We use two biophysical tools, an optical stretcher and a nove...

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Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties.

Neutrophils traversing the pulmonary microcirculation are subjected to mechanical stimulation during their deformation into narrow capillaries. To better understand the time-dependant changes caused by this mechanical stimulus, neutrophils were caused to flow into a microchannel, which allowed simultaneous visualization of cell morphology and passive rheological measurement by tracking the Brow...

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Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion.

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HIGHLIGHTED TOPIC Biomechanics and Mechanotransduction in Cells and Tissues Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties

Yap, Belinda, and Roger D. Kamm. Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties. J Appl Physiol 98: 1930–1939, 2005. First published January 7, 2005; doi:10.1152/japplphysiol.01226.2004.—Neutrophils traversing the pulmonary microcirculation are subjected to mechanical stimulation during their deformation into narro...

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Mechanical Deformation Accelerates Protein Ageing.

A hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile polymer. Ageing rates vary among different protein...

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ژورنال

عنوان ژورنال: Science Advances

سال: 2017

ISSN: 2375-2548

DOI: 10.1126/sciadv.1602536